Cozy Cheesy Beef & Biscuit Casserole Recipe: Family Favorite

Cheesy beef & biscuit casserole represents pure comfort food magic that upgrades simple ingredients into a mouthwatering meal.

Hearty flavors meld together in this classic dish that promises warmth and satisfaction for hungry families.

Home cooks appreciate how easily this recipe comes together with minimal preparation and maximum deliciousness.

Savory ground beef mingles with soft, buttery biscuits creating a rustic and irresistible combination that feels like a culinary hug.

Rich cheese blankets each layer, adding creamy depth and tantalizing texture to every single bite.

Weeknight dinners upgrade into memorable moments when this casserole emerges golden and bubbling from the oven.

The perfect balance of protein, carbohydrates, and melted cheese ensures everyone at the table will ask for seconds.

Biscuit Casserole Tips for Success

• Beef Browning Technique: Ensure ground beef is cooked completely and drained well to avoid excess grease in the casserole.
• Biscuit Coating Trick: Gently fold biscuits into meat mixture to prevent breaking, creating delicious bite-sized pieces throughout the dish.
• Cheese Distribution Secret: Shred cheese freshly for maximum melting and spread evenly across the top for consistent golden-brown coverage.
• Moisture Management: Don't overcook the meat mixture to maintain a juicy, flavorful base that keeps the biscuits from becoming dry.
• Baking Precision: Use an oven thermometer to confirm accurate temperature and rotate the pan halfway through baking for uniform browning.

How to Store and Reheat This Casserole

• Refrigeration: Store leftover casserole in an airtight container within 2 hours of cooking. Seal tightly and keep in the refrigerator for up to 3-4 days to maintain freshness and prevent bacterial growth.
• Reheating Oven Method: Preheat oven to 350°F. Place casserole in a baking dish, cover with foil to prevent drying, and warm for 15-20 minutes until heated through. Uncover during the last 5 minutes to restore crispy biscuit texture.
• Microwave Option: For quick reheating, place individual portions in a microwave-safe dish. Heat in 30-second intervals, stirring between each to distribute heat evenly. Stop when the casserole reaches steaming hot temperature throughout.

What Goes Well with Biscuit Casserole

• Pair with Zesty Salad: Toss a crisp garden salad with tangy vinaigrette to cut through the rich, cheesy beef casserole and add a refreshing crunch.
• Complement with Cool Beverage: Serve an ice-cold root beer or light amber beer to balance the hearty, savory flavors and provide a smooth drinking experience.
• Enhance with Pickled Side: Add quick-pickled cucumber or coleslaw to introduce a bright, acidic element that contrasts the warm, cheesy casserole and cleanses the palate.
• Round with Sweet Finish: Prepare a simple apple crisp or peach cobbler as dessert to end the meal with a sweet, comforting touch that echoes the casserole's homestyle charm.

Easy Recipe Variations to Try

• Spicy Southwest Beef Bake: Replace ketchup with salsa, add diced green chiles, and sprinkle pepper jack cheese for a zesty Mexican-inspired version.
• Mediterranean Lamb Fusion: Swap ground beef for ground lamb, incorporate oregano, mint, and crumbled feta cheese to create a Greek-style casserole.
• Barbecue Chicken Comfort: Substitute beef with shredded rotisserie chicken, mix in barbecue sauce instead of ketchup, and top with smoked gouda for a tangy alternative.
• Vegetarian Veggie Blend: Use plant-based ground meat, add mixed vegetables like bell peppers and mushrooms, and choose a dairy-free cheese to craft a meatless option.

Why You’ll Love Cheesy Beef & Biscuit Casserole

• Savor Speedy Comfort: This casserole delivers a quick and satisfying meal that combines hearty beef with soft, cheesy biscuits in under 45 minutes, perfect for busy weeknight dinners.
• Maximize Flavor Fusion: The combination of ketchup, brown sugar, Worcestershire sauce, and mustard creates a rich, tangy meat sauce that perfectly coats the biscuit pieces, ensuring every bite is packed with delicious flavor.
• Simplify Cooking Process: With just one skillet and a baking pan, this recipe offers minimal cleanup and straightforward preparation, making it ideal for home cooks who want a delicious meal without complex cooking techniques.
• Crowd-Pleasing Texture Blend: The crispy cheese topping, tender biscuit chunks, and savory beef mixture provide a delightful contrast of textures that will appeal to both kids and adults at family gatherings or casual dinners.

What Goes in Beef Biscuit Casserole

• Ground Beef: Lean protein that forms the base of the casserole, preferably fresh and low in fat.

• Ketchup, Brown Sugar, Worcestershire Sauce: Create a sweet and tangy flavor profile for the meat mixture.
• Mustard, Garlic Powder, Onion Powder, Salt: Add depth and enhance the overall savory taste of the dish.
• Water: Helps to create a moist and well-combined meat sauce.

• Refrigerated Biscuits: Convenient base that provides a soft, fluffy texture to the casserole.
• Cheddar Cheese: Sharp and melty cheese that adds richness and a golden-brown topping.

How to Make Beef Biscuit Casserole

Step 1: Prepare Oven and Baking Dish

Preheat oven to 350°F. Lightly coat a 9×13 inch baking pan with cooking spray.

Step 2: Cook Ground Beef

Brown ground beef in a skillet over medium heat until fully cooked. Drain excess fat.

Step 3: Create Flavorful Beef Sauce

• Ketchup
• Water
• Brown sugar
• Worcestershire sauce
• Mustard
• Garlic powder
• Onion powder
• Salt

Simmer the mixture for 5 minutes, stirring occasionally.

Step 4: Combine Beef and Biscuits

Remove beef mixture from heat and transfer to a medium bowl. Cut biscuits into quarters and gently mix with the beef until evenly coated.

Step 5: Assemble Casserole

Spread the beef and biscuit mixture into the prepared baking pan. Sprinkle shredded cheddar cheese evenly across the top.

Step 6: Bake to Perfection

Bake in the preheated oven for 28-30 minutes, or until the casserole turns golden brown.

Step 7: Serve and Enjoy

Remove from oven and let cool for a few minutes. Serve warm and savor the cheesy, hearty flavors.

Cheesy Beef & Biscuit Casserole Recipe

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4.7 from 33 reviews

• Total Time: 40 minutes
• Yield: 6 1x

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Description

Cheesy Beef & Biscuit Casserole brings comfort and hearty flavors straight from American kitchens. Savory ground beef melts with gooey cheese atop golden buttermilk biscuits, creating a satisfying meal you’ll crave again and again.

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Ingredients

Scale 1x2x3x

Meat:

• 1 pound (454 grams) ground beef

Dairy and Cheese:

• 1 cup (240 milliliters) cheddar cheese, shredded
• 12 ounces (340 grams) biscuits, cut into quarters

Seasonings and Sauces:

• ¾ cup (180 milliliters) ketchup
• ¼ cup (60 milliliters) water
• 3 teaspoons brown sugar
• 2 teaspoons Worcestershire sauce
• 2 teaspoons mustard
• 1 teaspoon garlic powder
• 1 teaspoon onion powder
• ¼ teaspoon salt

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Instructions

1. Prepare the oven by heating to 350°F (177°C) and thoroughly coat a 9×13-inch (23×33 centimeters) baking dish with cooking spray.
2. Place ground beef in a skillet over medium heat and cook thoroughly, breaking into small crumbles until no pink remains, then carefully drain excess fat.
3. Incorporate ketchup, water, brown sugar, Worcestershire sauce, mustard, garlic powder, onion powder, and salt into the cooked beef, allowing the mixture to simmer and develop rich flavors for approximately 5 minutes.
4. Transfer the seasoned beef mixture to a medium-sized mixing bowl and let it cool slightly.
5. Cut refrigerated biscuits into quarters, then gently fold these pieces into the beef mixture, ensuring each biscuit segment is evenly coated.
6. Distribute the biscuit and beef combination uniformly across the prepared baking dish, creating an even layer.
7. Generously sprinkle shredded cheddar cheese over the entire surface, covering the casserole completely.
8. Place the casserole in the preheated oven and bake for 28-30 minutes, or until the top turns golden brown and the cheese melts completely.
9. Remove from the oven and allow to rest for 3-5 minutes before serving hot.

Notes

• Maximize flavor by simmering the beef with a tangy blend of ketchup, brown sugar, and Worcestershire sauce for a rich, caramelized taste.
• Ensure even cooking by thoroughly mixing quartered biscuits with the seasoned meat before spreading in the baking pan.
• Sprinkle sharp cheddar cheese generously on top for a melty, golden-brown crust that adds extra indulgence to the casserole.
• Save time with this one-pan meal that combines protein, carbs, and cheese in a comforting, family-friendly dish.
• Quick tip: Drain excess fat from beef to prevent a greasy texture and maintain the casserole’s appetizing consistency.
• Serve immediately while the cheese is still melted and the biscuits are warm for the best dining experience.

• Prep Time: 10 minutes
• Cook Time: 30 minutes
• Category: Breakfast, Dinner
• Method: Baking
• Cuisine: American

Nutrition

• Serving Size: 6
• Calories: 380 kcal
• Sugar: 8 g
• Sodium: 620 mg
• Fat: 22 g
• Saturated Fat: 10 g
• Unsaturated Fat: 10 g
• Trans Fat: 0.5 g
• Carbohydrates: 26 g
• Fiber: 1 g
• Protein: 23 g
• Cholesterol: 75 mg